Research
Prism shares Astera Institute’s commitment to radical transparency. By publishing our work as it happens, we aim to maximize its potential for broad impact and reuse.
All of our research outputs are completely open, exist outside of traditional scientific journals, and aim to be FAIR: Findable, Accessible, Interoperable, and Reusable.
Below are our research posts, where we share our methods, tools, and results. In addition, we maintain the DiffUSE Logbook, a separate and continuously updated record of X-ray datasets, synchrotron notes, data processing reports, and preliminary analysis, published as experiments are completed. Explore the DiffUSE Logbook →
- Biology
How Silent Code Updates Can Alter Protein Predictions
Software updates can alter protein structure predictions even when model weights stay fixed. A Protenix case study shows why reproducibility requires tracking the entire prediction pipeline.
- Blog
- Data Collection
- and Modeling, General, Biology, and Encoding
The Vision for Prism
Charting the course for dynamic structural biology.
- Blog
- Data Collection
- and Modeling, Biology, and Infrastructure
A Year (plus) of DiffUSE
Science progress over the first year-ish of the DiffUSE Project
- Blog
- Data Collection
- and Modeling, Biology, and Infrastructure
Expanding The DiffUSE Project
Expanding The DiffUSE Project
- Blog
- Data Collection
- and Modeling, Biology, and Infrastructure
Quarterly All-Hands Meeting Summary
A report on our October 2025 all-hands meeting
- Blog
- Data Collection
- and Modeling, Biology, and Infrastructure
From systems operators to systems architects
Opens on seemay.substack.com/p/from-systems-operators-to-systems
Going up a level from data generation to think about the data systems we design and embed
- Blog