Our Science

Revealing the
Dynamics of Life

The era of static structure prediction has arrived. But static structures cannot tell us what makes an enzyme functional, what drives drug specificity, or how to engineer motion itself.
Overview

Prism is making molecular motion measurable, predictable, and actionable. This will transform how we discover drugs, design biology, and understand disease.

Function emerges from the ensembles of conformations a protein adopts and from the motions between them. How that motion drives biology remains uncharted. Making this link actionable would transform drug discovery, enzyme design, synthetic biology, and human health.
We are in an era of algorithmic abundance. But to empower these algorithms requires the right data, models, and encodings. Much of the technology and infrastructure to measure these ensembles still doesn't exist. Prism is building it.

Why we need to tackle the full stack to transform structural biology

Better models are useless if the machine learning algorithms cannot represent this motion. New data is wasted if the processing removes motion. Progress is limited by the weakest stage.
Transforming structural biology requires coordinated change at every stage of the pipeline, and at the points where those stages meet.
Samples, Data collection, Data processing feed the Prism pipeline, which produces Modeling, Encoding, Interpretation.SAMPLESDATA COLLECTIONDATA PROCESSINGMODELINGENCODINGINTERPRETATION
Project areas

Four focus areas

Our four focus areas work together, linking data collection methodology, modeling, infrastructure, and biological impact. Each advances the others, building the foundation needed to measure, predict, and act on protein motion.